Episode 07: How can patients be safely withdrawn from their psychiatric drugs


Training Psychiatrist and Clinical Research Fellow in the UK National Health Service, Mark Horowitz, has published guidance about how to withdraw safely from psychiatric drugs. In this episode, Peter C Gøtzsche interviews Mark Horowitz who gives practical advice about how to taper the drugs in a hyperbolic fashion. He also recounts his personal experience of horrific withdrawal symptoms when he tried to withdraw a depression drug and did not know how to do it.


Horowitz MA, Taylor D. Tapering of SSRI treatment to mitigate withdrawal symptoms. Lancet Psychiatry 2019;6:538-46 (behind a paywall).

Horowitz M, Taylor DM.The Maudsley Deprescribing Guidelines: Antidepressants, Benzodiazepines, Gabapentinoids and Z-drugs (The Maudsley Prescribing Guidelines Series) 2024.

Gøtzsche PC. Mental health survival kit and withdrawal from psychiatric drugs. Ann Arbor: L H Press; 2022.

Gøtzsche PC. Withdrawing from psychiatric drugs: How to produce smaller doses than those the drug companies provide. Mad in America 2023; Nov 21.

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